Animal Experiments for Assessment of Skeletal Muscle Mechanics in situ - with measurement of forces of muscles of a whole compartment, simultaneously
Finite Element Modeling for Computational Assessment of Mechanics of Muscle Tissue - with a bi-domain (fiber & extracellular matrix) approach
Intra-operative Experiments in Human Muscles for Assessment of Muscle Force - Joint Angle Relationship
Magnetic Resonance & Difusion Tensor Imaging for Assessment of Human Tissue Deformation in vivo (in colaboration with BU-BME Medical Imaging Lab. and with BU-EEE Volumetric Analysis & Visualization Group VAVlab)
Analyses of Human Movement (in colaboration with İU-İstanbul Tıp Faculty)
Mechanical Testing (in colaboration with Tissue Lab)
Histology (in colaboration with Tissue Lab)
The Research Capabilities listed above are employed in combinations in order to address biomechanics problems particularly related to the musculo-skeletal system both computationally and experimentally. Research is conducted based on new viewpoints developed.
A central issue is myofascial force transmission i.e., transmission of muscle force via structures coupling mechanically (i) muscle fibers and the extracellular matrix along the full length of muscle fibers and (ii) muscle to its surrounding muscular and non-muscular structures along the muscle belly. Due to such force transmission, our research groups have shown evidence that individual muscle fibers as well as individual muscles are not mechanically independent entities. This means that the force and movement production capacity of a particular muscle is not a unique property of it. Instead, such capacity is variable depending on the mechanical conditions within which the muscle functions. This has numerous implications for normal muscle function as well as for pathological muscle function. The Biomechanics Lab is interested in studying these implications and proposing new understandings for muscle performance in health and pathological conditions and for treatment techniques.
Currently, we are particularly interested in
i) Spasticity, aiming at improving the understanding of the mechanism of effects causing impeded joint function.
ii) Remedial Surgery, such as muscle lengthening surgery in order to understand systematically the mechanical mechanism of effects within the muscle interfered as well as for other muscles.
iii) Botulinum Toxin Injections, in order to quantify the length dependency of muscle force reduction effect and to understand its mechanism.
iv) Therapies such as kinesio taping, aiming at understanding mechanism of effects objectively and in detail using magnetic resonance imaging analyses.
See a recording of Dr Yücesoy's invited lecture in European College of Sports Sciences Amsterdam 2014 Conference for a covering of recent findings and concepts on muscular force transmission mechanisms with sevral implications: https://www.youtube.com/watch?v=aOFbwzlTThk&index=3&list=PL5_3zE0LicHpB9e76aX9qQuMa-mTn_In2
XXI Congress of the International Society of Electrophysiology and Kinesiology (ISEK 2016 (http://www.isek.org/?page_id=230) will be held in July 5-8, 2016, Chicago, Illinois, USA.
Dr. Yücesoy is organizing a symposium in ISEK 2016 which is entitled: Spastic muscle and its treatment using botulinum toxin: new wievpoints with major implications. The speakers of the symposium include Rick Lieber, Adam Shortland, abrina Lee, Filiz Ates, Rafael Fortuna and Can A. Yucesoy.
Symposium motives are: Often global movement of the patients is studied in assessing effects of spastic cerebral palsy (CP) and effectiveness of spasticity management using botulinum toxin (BTX). Although this does offer an objective evaluation, the findings can be inconclusive or they are frequently inconsistent. This implies an insufficient control over the treatment of the movement disorder. This is in part ascribable to the heterogeneous conditions of CP patients. However, a major issue is that there is no sufficient understanding of the specific causes of the impeded joint movement, which may be obscured by the outcomes of the global bodily movement studied. Spastic muscle is still the motor for movement. Therefore, quantification of individual spastic muscle’s properties and measurement of its potential for affecting the joint mechanics is of key importance. On the other hand, a good understanding of the mechanism of effects of BTX on muscle mechanics and structure is crucial, but lacking. This treatment aims at reducing passive resistance, increasing joint range of movement and establishing a more balanced muscle force. Therefore, specifically testing of treated muscle’s stiffness, passive force, length range of active force production and mechanism of active force reduction is essential. This symposium will address these issues. Key symposium aims are the following: (1) Shedding light on the indicated gaps in our understanding by showing substantial data, (2) providing a platform for addressing different opinions among the speakers and (3) bridging specific muscle related findings back with the context of joint movement and suggesting new research directions.
The speakers of this symposium have been engaging with direct research questions on spastic muscle and its treatment using BTX based on motives described above and showing remarkable findings, leading to new viewpoints with major implications. Their research involves various methodologies including additional to clinical assessments, intraoperative experiments on CP patients to measure forces of spastic muscles directly as a function joint angle, ultrasound techniques to identify structural muscle tissue adaptations and altered stiffness, animal experiments to specifically quantify BTX effects on muscle function and structure, and mathematical modeling to characterize mechanism of effects of BTX on muscular mechanics.
Biomedical Engineering Institute,
34684 Çengelköy, Istanbul
Tel: + 90 216 516 44 48